Novel Optics, Ningbo Yongxin Optics Co., Ltd.

One‑click switching: dive deeper into the nanoworld

√ Brightfield, Phase‑contrast, Fluorescence, DIC

√ Laser Confocal

√ 2D‑SIM / 3D‑SIM / TIRF‑SIM

Built upon the NIB1000 research‑grade inverted microscope, the system incorporates both SIM super‑resolution and confocal technologies. Research on precious samples is no longer limited to a single imaging modality, but supports multi‑dimensional scientific analysis.

Covering conventional imaging modalities including transmitted wide‑field, fluorescence wide‑field, oblique‑incidence wide‑field, and multi‑angle TIRF wide‑field, the NSR1000 integrates confocal and super‑resolution capabilities into one unified system, forming an almost complete life‑science microscopy imaging solution.

More information, faster acquisition speed

Large Field‑of‑View

Even at 100× magnification, the NSR1000 maintains a large field‑of‑view. This provides superior conditions for observing and analysing large‑area samples at the microscale. While preserving ultra‑high resolution, it supports simultaneous examination of both overall sample features and local fine details, significantly boosting workflow efficiency and research insight.

Video‑rate real‑time super‑resolution: “what you see is what you get”

SIM delivers highly‑efficient super‑resolution reconstruction. Interleaved reconstruction mode further improves temporal resolution and throughput during live real‑time reconstruction, allowing direct observation of fast dynamic processes at super‑resolution. The interleaved reconstruction mode also works for offline reconstruction of previously‑acquired datasets, improving data utilisation and enhancing temporal resolution for both 2D and 3D super‑resolution imaging.

Higher resolution to reveal sub‑cellular ultrastructural details

Axial super‑resolution (3D‑SIM): down to 270nm

Adopting three‑beam phase‑shifting structured‑light interference technology to achieve axial optical sectioning. The system achieves a greatly‑improved axial resolution of 270nm. The NSR1000 can resolve three‑dimensional architectures within biological samples with remarkable clarity, which is especially valuable for studying fine features deep inside specimens.

Lateral resolution (2D‑SIM): doubled performance

Powered by structured‑illumination microscopy, the NSR1000 doubles lateral resolution. Paired with the 100× high‑NA plan‑apochromatic objective lens (NA 1.49), it reaches 85 nm resolution and resolves delicate structures such as mitochondrial cristae, delivering unprecedented insight and accuracy for life‑science research.

AI‑enhanced resolution up to 60 nm

With the integrated AI module, imaging resolution can be further improved to 60 nm. It reveals finer structural details for observations of cellular architecture and molecular interactions, advancing research in biochemistry, cell biology and related disciplines, and providing researchers with a powerful visualisation tool.

Comprehensive Software Platform: Nomis Pro X‑CS for Powerful Analysis & Visualisation

Nomis Pro X‑CS is Nexcope’s custom‑built software for super‑resolution and confocal microscopy. It achieves highly integrated hardware control for super‑resolution and confocal systems together with core microscope functions, seamlessly combined with data‑analysis workflows. It forms an all‑in‑one experimental platform featuring outstanding performance and intuitive operation.

Thanks to its superior system integration and flexible adaptability, it handles complex research scenarios and specialised experimental requirements. Users benefit from smooth workflows, freeing them from tedious manual microscopy operations so they can focus on scientific exploration and innovation.

Comprehensive Software Platform: Nomis Pro X‑CS for Powerful Analysis & Visualisation

Nomis Pro X‑CS is Nexcope’s custom‑built software for super‑resolution and confocal microscopy. It achieves highly integrated hardware control for super‑resolution and confocal systems together with core microscope functions, seamlessly combined with data‑analysis workflows. It forms an all‑in‑one experimental platform featuring outstanding performance and intuitive operation.

Thanks to its superior system integration and flexible adaptability, it handles complex research scenarios and specialised experimental requirements. Users benefit from smooth workflows, freeing them from tedious manual microscopy operations so they can focus on scientific exploration and innovation.

Flexible imaging solutions built on the NIB1000 platform

Filter blocks

Fast switching and highly‑accurate positioning, enabling rapid transitions between different observation modes.

XY motorised stage

Highly responsive movement and stable positioning, with intuitive joystick control for effortless operation.

Observation modules

User‑friendly controls and seamless modality switching to build an efficient imaging environment for researchers.

Joystick with Built‑in Touch Panel

Equipped with an integrated touch screen, the joystick allows configuration of instrument status, stepped control for the motorized stage and motorized focusing. It also features dedicated function keys and an AFS button.

AFS delivers stable and reliable imaging performance

The NIB1000 features an independent focusing design to minimize the influence of other mechanical components on the Z‑axis. The newly‑developed Adaptive Focus System (AFS) intelligently eliminates focus shift.

Whether paired with high‑magnification objectives of large numerical aperture, or applied for cutting‑edge imaging techniques such as super‑resolution, confocal and TIRF, it consistently delivers clear and sharp images.

The live‑cell incubation system

Purpose‑built for precise live‑cell imaging. It accurately controls the temperature of the microscope stage, maintaining constant temperature, humidity and CO₂ concentration inside the culture dish to provide an ideal incubation environment for long‑term experiments.