Novel Optics, Ningbo Yongxin Optics Co., Ltd.

NCF1000 Laser Confocal Microscope

Life‑science research has growing demands for analysing tissues, organs and model organisms, and high‑efficiency imaging has become critical for scientific breakthroughs. Large‑specimen imaging requires both broader coverage and faster speed to accurately capture intracellular dynamic responses. To address this need, we introduce the NCF1000‑series laser confocal microscope, engineered to meet high‑throughput, high‑quality imaging requirements for modern biology. Delivering a large field‑of‑view, high resolution and fast acquisition speed, it produces superior‑quality images with sharp contrast and true‑to‑life colours. It supports in‑depth exploration at the cellular nanoscale, enables intuitive and precise interpretation of biological processes, and expands the boundaries of scientific research.

Overview

Acquire a large field‑of‑view and full‑specimen information within short time

Extract More Data from Specimens
The NCF1000 confocal microscope offers a large field‑of‑view, delivering 1.5× higher throughput and up to 8192 × 8192‑pixel scanning for tissues, organs and live model organisms.

Fewer Tiles for Large‑Image Stitching
Working with the NIB1000 platform, its 25 mm field‑of‑view cuts stitching tiles and scan time, enabling high‑throughput imaging of large specimens.

Achieve higher signal‑to‑noise ratio and superior image resolution

High‑performance objectives for confocal imaging

The NIS‑series objectives offer high numerical aperture, long working distance and excellent chromatic aberration correction. Multi‑layer coating technology delivers outstanding image quality and resolution. Ideal for conventional light microscopy, NIS‑series objectives also play a vital role within confocal systems. They help researchers capture previously‑unseen fine structures and dynamic events, supporting deep exploration and visualisation of the micro‑world.

High‑efficiency scanner and detector

The NCF1000‑series integrates a high‑precision galvanometer scanning system and infinitely‑variable motorised pinhole inside the scanner unit, enabling low‑noise, high‑contrast, high‑quality confocal imaging. It supports scanning up to 8192 × 8192 pixels. Even with low‑magnification objectives, it achieves exceptional high‑precision sampling beyond optical diffraction limits, ensuring faithful capture and reproduction of micro‑scale details.

High‑sensitivity and accurate spectral‑unmixing system

Equipped with GaAsP photomultiplier tubes (PMTs), the NCF1000 improves fluorescence collection efficiency, allowing observation of faint‑fluorescence samples that are difficult to detect with conventional instruments. The system supports up to four distinct spectral ranges with spectral resolution ≤ 3 nm. It effectively suppresses background noise under low excitation‑light intensity and delivers excellent multi‑colour confocal imaging performance.

* This function applies only to the NCF1000 model.

Shortened acquisition time for high‑frequency confocal imaging

Faster scanning speed

High‑speed imaging performance reaches up to 60 fps (8 × 256 pixels). It reduces specimen exposure under high light density and significantly lowers phototoxicity. Fast scanning enables high‑frequency data acquisition to capture dynamic events and long‑term changes within samples. Real‑time recording and analysis are performed reliably to satisfy complex and stringent imaging requirements across life‑science research.

Real‑time four‑channel simultaneous imaging

Adopting cutting‑edge four‑channel fluorescence fusion technology, the NCF1000 confocal microscope allows researchers to perform precise multi‑channel synchronous observation and capture in real time. Four different fluorescent labels can be detected and analysed within a single field‑of‑view. Seamless signal switching and fusion work together with precise spectral‑unmixing imaging to vividly reveal multi‑layered and multi‑dimensional complex information inside specimens. It greatly improves experimental throughput and data accuracy.

Comprehensive Software Platform for Powerful Analysis & Visualization

Nomis Pro X‑C

High‑speed Hardware Control: Intuitive digital management and precise control of multiple motorised components inside the microscope.

Multi‑dimensional Imaging & Image Display: Supports combined X, Y, Z, λ, T scan modes, with multiple flexible built‑in shooting presets.

Deconvolution: Performs deblurring for 2D images. Multiple rounds of deconvolution can be applied to eliminate shot‑noise components in confocal images.

Comprehensive Software Platform for Powerful Analysis & Visualization

Nomis Pro X‑C

High‑speed Hardware Control: Intuitive digital management and precise control of multiple motorised components inside the microscope.

Multi‑dimensional Imaging & Image Display: Supports combined X, Y, Z, λ, T scan modes, with multiple flexible built‑in shooting presets.

Deconvolution: Performs deblurring for 2D images. Multiple rounds of deconvolution can be applied to eliminate shot‑noise components in confocal images.

High‑performance Confocal Microscopy Platform

The research‑grade NIB1000 inverted microscope series and NE900 upright microscope series deliver powerful and flexible imaging solutions, forming a robust, highly‑expandable microscopy foundation for the NCF1000 confocal system.

- High‑speed motorised control
- Interactive operation
- Large‑aperture optical system
- Live‑cell incubation system
- Adaptive Focus System (AFS)

High‑performance Confocal Microscopy Platform